RESEARCH LIBRARY

In this 36-week phase 2 trial in adults with type 2 diabetes, the authors reported dose-dependent reductions in HbA1c and body weight versus placebo, with a safety profile consistent with the incretin class (predominantly mild-to-moderate gastrointestinal events).

DOI: 10.1016/S0140-6736(23)01053-X

In this 48-week phase 2 trial in adults with obesity, the authors reported mean weight reductions of up to 24.2% at the highest dose versus 2.1% with placebo, with dose-dependent effects and mostly gastrointestinal adverse events.

DOI: 10.1056/NEJMoa2301972

This review summarizes preclinical research on the stable gastric pentadecapeptide BPC 157, reporting cytoprotective and healing effects across gastrointestinal-tract lesion models in animals and noting its stability in human gastric juice.

DOI: 10.2174/138161211796196954

In a rat medial collateral ligament transection model, the authors reported that BPC 157 — given systemically or locally — improved functional, biomechanical, and histological measures of ligament healing versus controls.

DOI: 10.1002/jor.21107

In rodent wound models, the authors reported that thymosin beta-4 promoted angiogenesis, accelerated dermal wound repair, and stimulated hair-follicle development.

DOI: 10.1016/j.mad.2003.11.005

In healthy adults, single injections of CJC-1295 produced dose-dependent increases in growth hormone (2- to 10-fold) and IGF-I (1.5- to 3-fold) that persisted for up to 6 or more days, consistent with the compound's long half-life (about 6-8 days).

DOI: 10.1210/jc.2005-1536

In rodent studies, the authors reported that Semax activated brain dopaminergic and serotoninergic systems, increasing striatal dopamine and serotonin turnover — mechanistic context for its study as a nootropic peptide.

DOI: 10.1007/s11064-005-8826-8

In this clinical study of patients at different stages of ischemic stroke, the authors reported that adding Semax to standard therapy was associated with improved neurological outcome measures compared with standard therapy alone.

DOI: 10.17116/jnevro20181183261-68